BONE REGENERATION IN CRITICAL-SIZE CALVARIAL DEFECT IN RATS USING INNOVATIVE NANO COMPOSITE MATERIAL OF CHITOSAN/NANO-HYDROXYAPATITE COMPOSITE

Authors

  • Petar Dimitrov Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Elena Dyulgerova Medical University, Faculty of Dental Medicine, Sofia, Bulgaria
  • Radost Ilieva Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Radosveta Vasileva Medical University, Faculty of Dental Medicine, Sofia, Bulgaria
  • Veselin Nanev Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Ivelin Vladov Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Margarita Gabrashanska Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Marin Alexandrov Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Neli Tsocheva-Gaytandzhieva Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria

Keywords:

calvarial defect in rats, chitosan/nano-hydroxyapatite, bone regeneration

Abstract

Healing of standardized critical-size calvarial defects in rats was performed with nano composite material of nano-hydroxyapatite/3 % solution of chitosan in citric acid, and electrospinning fibres of poly lactic acid. Histologically at the 84 day, the implanted rats exhibited full closure of the defect by new developed connective and osteoid tissues penetrating in reticular pattern within the implant components. These results indicate that by using a newly created composite paste critical cranial defects can be successfully retrieved and probably is also suitable for other cases in bone augmentation surgeries.

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Published

2017-06-20

How to Cite

Dimitrov, P., Dyulgerova, E., Ilieva, R., Vasileva, R., Nanev, V., Vladov, I., … Tsocheva-Gaytandzhieva, N. (2017). BONE REGENERATION IN CRITICAL-SIZE CALVARIAL DEFECT IN RATS USING INNOVATIVE NANO COMPOSITE MATERIAL OF CHITOSAN/NANO-HYDROXYAPATITE COMPOSITE. TRADITION AND MODERNITY IN VETERINARY MEDICINE, 2(1), 17–20. Retrieved from https://www.scij-tmvm.com/index.php/pub/article/view/25

Issue

Vol. 2 No. 1 (2017): Volume 2 Issue 1 (2017)

Section

Articles

License

Copyright (c) 2017 TRADITION AND MODERNITY IN VETERINARY MEDICINE

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This work is licensed under a Creative Commons Attribution 4.0 International License.