INFLUENCE OF THE IMMUNOMODULATOR "AVIGEN" ON THE NATURAL RESISTANCE OF ROSS HYBRID BROILER

Abstract

Some basic indicators of nonspecific immunity in ROSS 308 hybrid broilers receiving a polybacterial immunomodulator were studied by enzyme-linked immunosorbent assay and spectrophotometric methods. The experiments were performed in flocks of broiler breeders and broilers under production conditions. In the control herds- under the same breeding conditions and in compliance with the prophylactic programs in the farms, including the accepted antibiotic therapy. The birds from the experimental flocks were raised without the use of antibiotics. As a result of the performed studies, we found higher concentrations of lysozyme, IFN γ, IL-2; IL-6 in experimental herds receiving the immunomodulator compared to controls. For example, in the experimental broiler herd, we found twice as high levels of serum lysozyme relative to controls: 6.17 ± 0.49 mg / L and 2.99 ± 0.27 mg / L, respectively. The activity of complement (CH50) in the blood serum of broilers treated with AVIGEN - 549.00 ± 19.69, also significantly exceeded the values in the control herd - 377.40 ± 9.58. We received similar results from broiler breeders. Serum IgY concentrations showed a significant difference in adolescent broiler breeders but not in broilers. We tracked the changes in bursa Fabricii by histological methods. Under the influence of the immunomodulator AVIGEN in the bursa of experimental birds, we observed delayed involution and good functional activity, while in the controls, involution processes were advanced and accompanied by follicle death and connective tissue growth. The morphological and functional activity of bursa Fabricii contributes to the increased natural resistance in the birds treated with the immunomodulator, which enabled their breeding without the use of antibiotics in production conditions.