HEPATIC PRENEOPLASIA INDUCED BY N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE IN JAPANESE QUAIL EMBRYOS

Authors

  • Branimir Nikolov Institute of Experimental, Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Ani Georgieva Institute of Experimental, Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Roman Pepovich University of Forestry, Faculty of Veterinary Medicine, Sofia, Bulgaria
  • Kalin Hristov University of Forestry, Faculty of Veterinary Medicine, Sofia, Bulgaria
  • Tandzhu Mehmedov University of Forestry, Faculty of Veterinary Medicine, Sofia, Bulgaria
  • Vasil Manov University of Forestry, Faculty of Veterinary Medicine, Sofia, Bulgaria
  • Elena Nikolova National Diagnostic and Research Veterinary Medical Institute, Sofia, Bulgaria
  • Reneta Petrova National Diagnostic and Research Veterinary Medical Institute, Sofia, Bulgaria
  • Ivelin Vladov Institute of Experimental, Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Anton Kril Institute of Experimental, Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria

Keywords:

hepatocarcinogenesis, preneoplasia, avian embryos, japanese quail, N-nitrosodimethylamine, N-nitrosodiethylamine

Abstract

Toxic and carcinogenic effects induced in ovo by N-nitrosodimethylamine and N-nitrosodiethylamine in Japanese quail embryos were studied by histopathological methods. The obtained results indicate that both compounds induce preneoplastic hepatic alterations. The spectrum of macroscopic and microscopic lesions identified in carcinogen-treated embryos has been presented. The significance of avian embryos as an inexpensive and reliable model system for studies on hepatocarcinogenesis has been briefly discussed.

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Published

2016-07-14

How to Cite

Nikolov, B., Georgieva, A., Pepovich, R., Hristov, K., Mehmedov, T., Manov, V., … Kril, A. (2016). HEPATIC PRENEOPLASIA INDUCED BY N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE IN JAPANESE QUAIL EMBRYOS. TRADITION AND MODERNITY IN VETERINARY MEDICINE, 1(1), 21–25. Retrieved from https://www.scij-tmvm.com/index.php/pub/article/view/11

Issue

Vol. 1 No. 1 (2016): Volume 1 Issue 1 (2016)

Section

Articles

License

Copyright (c) 2016 TRADITION AND MODERNITY IN VETERINARY MEDICINE

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This work is licensed under a Creative Commons Attribution 4.0 International License.